ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relative contribution of fat mass and lean mass on bone mineral density (BMD) in premenopausal healthy women.</p><p><b>METHODS</b>The BMD at lumbar spine, proximal femur and total body, together with fat mass and lean mass was determined by dual-energy X-ray absorptiometry (DEXA), the body height, weight, waist, and hip circumference were also measured, and body mass index (BMI) and waist-hip ratio were calculated in 282 premenopausal women.</p><p><b>RESULTS</b>Fat mass was a major determinant for BMI, BMI and lean mass were positively related with L2-4, proximal femur and total body BMD (P = 0.000 for all), and lean mass were the only independent factor contributing to L2-4 (standardized coefficient beta = 0.282, P = 0.000), proximal femur (beta = 0.336, P = 0.000) and total body BMD (beta = 0.361, P = 0.000) in stepwise regression analysis. The relationship between BMI and BMD was further improved after controlling fat mass, while decreased or even lost when controlling lean mass.</p><p><b>CONCLUSIONS</b>Lean mass was an important factor determining BMD in premenopausal women.</p>
Subject(s)
Adult , Female , Humans , Middle Aged , Absorptiometry, Photon , Body Composition , Body Mass Index , Bone Density , PremenopauseABSTRACT
<p><b>OBJECTIVE</b>To investigate the association of calcitonin receptor (CTR) gene polymorphism with bone mineral density (BMD) in premenopausal and postmenopausal women.</p><p><b>METHODS</b>CTR genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 184 premenopausal women and 199 postmenopausal women in Shanghai area. BMD at lumbar spine (L2-4) and femoral neck (FN) were measured by dual-energy X-ray absorptiometry (DEXA).</p><p><b>RESULTS</b>The distribution of CTR genotypes in 383 Shanghai women were CC genotype 83.8%, TC genotype 14.6%, TT genotype 1.6%, respectively. BMD at FN of CC genotype was significantly higher than TC and TT genotypes (P < 0.01) in postmenopausal women. But there was no difference in BMD of different CTR genotypes in premenopausal women. Multiple regression analysis showed that CTR genotypes were associated with FN BMD in postmenopausal women (P < 0.05).</p><p><b>CONCLUSIONS</b>The polymorphism of CTR gene was associated with BMD in postmenopausal women.</p>